Search results for "Philadelphia negative"

showing 5 items of 5 documents

Genetics and Pathogenetic Role of Inflammasomes in Philadelphia Negative Chronic Myeloproliferative Neoplasms: A Narrative Review

2021

The last decade has been very important for the quantity of preclinical information obtained regarding chronic myeloproliferative neoplasms (MPNs) and the following will be dedicated to the translational implications of the new biological acquisitions. The overcoming of the mechanistic model of clonal evolution and the entry of chronic inflammation and dysimmunity into the new model are the elements on which to base a part of future therapeutic strategies. The innate immune system plays a major role in this context. Protagonists of the initiation and regulation of many pathological aspects, from cytokine storms to fibrosis, the NLRP3 and AIM2 inflammasomes guide and condition the natural hi…

0301 basic medicinechronic inflammationInflammasomesmyeloproliferative neoplasmAIM2Context (language use)DiseaseReviewBioinformaticsSomatic evolution in cancerCatalysismyeloproliferative neoplasmsLeukemia Myeloid Chronic Atypical BCR-ABL NegativeAutoimmune Diseaseslcsh:ChemistryInorganic ChemistryClonal Evolution03 medical and health sciencesAIM20302 clinical medicineNLRP3inflammasomeNLR Family Pyrin Domain-Containing 3 ProteinmedicineHumansPhysical and Theoretical Chemistrylcsh:QH301-705.5Molecular BiologySpectroscopyPhiladelphia negativeInflammationInnate immune systembusiness.industryOrganic ChemistryInflammasomeGeneral MedicineComputer Science ApplicationsNatural historyDNA-Binding Proteins030104 developmental biologylcsh:Biology (General)lcsh:QD1-999030220 oncology & carcinogenesisbusinessmedicine.drugInternational Journal of Molecular Sciences
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How the coronavirus pandemic has affected the clinical management of Philadelphia-negative chronic myeloproliferative neoplasms in Italy—a GIMEMA MPN…

2020

Since early 2020, the SARS-CoV-2 pandemic has a massive impact on health care systems worldwide. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. Here, we provide recommendations for the management of patients with malignant disease in the times of COVID-19. These recommendations were prepared by an international panel of experts and then consented by the EHA Scientific Working Group on Infection in Hematology. The primary aim is to enable clinicians to provide optimal cancer care as safely…

2019-20 coronavirus outbreakCancer ResearchPneumonia ViralDiseasesSevere Acute Respiratory Syndromemedicine.disease_causeBetacoronavirusMyeloproliferative DisordersNeoplasmsSurveys and QuestionnairesPandemicmedicineHumansPandemicsCoronavirusPhiladelphia negativeMyeloproliferative DisordersbiologySARS-CoV-2business.industryHealth careCOVID-19Hematologymedicine.diseasebiology.organism_classificationVirologyCoronavirusPneumoniaItalyOncologyPerspectiveCoronavirus InfectionsbusinessCoronavirus InfectionsBetacoronavirusBetacoronavirus COVID-19 Humans Italy SARS-CoV-2 Surveys and Questionnaires Coronavirus Coronavirus Infections Myeloproliferative Disorders Neoplasms Pandemics Pneumonia Viral Severe Acute Respiratory Syndrome
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COVID-19 in Philadelphia-negative myeloproliferative disorders: a GIMEMA survey

2020

2019-20 coronavirus outbreakPediatricsmedicine.medical_specialtyCancer ResearchCoronavirus disease 2019 (COVID-19)EpidemiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralPhiladelphia chromosomeSeverity of Illness IndexMyeloproliferative diseaseBetacoronavirusMyeloproliferative DisordersLeukemia Myelogenous Chronic BCR-ABL PositiveCorrespondenceNitrilesmedicineHumansPhiladelphia ChromosomeBetacoronavirus COVID-19 Coronavirus Infections Cross-Sectional Studies Disease Progression Humans Italy Leukemia Myelogenous Chronic BCR-ABL Positive Philadelphia Chromosome Pneumonia Viral Pyrazoles SARS-CoV-2 Severity of Illness Index Survival Analysis PandemicsPandemicsPhiladelphia negativebusiness.industrySARS-CoV-2Disease progressionCOVID-19Hematologymedicine.diseaseSurvival AnalysisCross-Sectional StudiesPyrimidinesItalyOncologyDisease ProgressionPyrazolesbusinessCoronavirus InfectionsCoronavirus InfectionsLeukemia
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Age at diagnosis is an important prognostic factor in Philadelphia-negative Myeloproliferative Neoplasms

2019

Oncologymedicine.medical_specialtyPrognostic factorPrognosiMEDLINEAge at diagnosisPhiladelphia chromosomeMyeloproliferative DisordersInternal medicinemedicineBiomarkers TumorHumansAge FactorPhiladelphia ChromosomeAge of OnsetMyeloproliferative DisorderPhiladelphia negativeMyeloproliferative Disordersbusiness.industryAge FactorsHematologyGeneral Medicinemedicine.diseasePrognosisAge of onsetbusinessHuman
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Evaluation of thrombin generation in classical Philadelphianegative myeloproliferative neoplasms / Evaluarea generării trombinei în neoplasmele mielo…

2016

Abstract Introduction: Patients with Philadelphia-negative chronic myeloproliferative neoplasms (Ph-MPN), polycytemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF), are prone to develop thrombotic events. We aimed to investigate the coagulation status in their plasma using thrombin generation assay (TGA), a functional global assay, on Ceveron® Alpha. Materials and methods: The samples were collected from 89 consecutive Ph-negative MPN patients and from 78 controls into K2EDTA and CTAD tubes for blood cell counts, TGA and coagulation screening tests. Thrombin generation was analysed in platelet-poor plasma using Technothrombin® TGA assay kit. Results: We found a …

Philadelphia negativeessential thrombocythemiaidiopatic myelofibrosisbusiness.industryR030204 cardiovascular system & hematologyThrombin generation03 medical and health sciences0302 clinical medicinepolycythemia verahemic and lymphatic diseasesthrombin generationCancer researchMedicineMedicinebusinessthrombosis030215 immunologyRomanian Journal of Laboratory Medicine
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